Quantitative magnetization transfer imaging in postmortem multiple sclerosis brain
نویسندگان
چکیده
منابع مشابه
A Novel Classification Method using Effective Neural Network and Quantitative Magnetization Transfer Imaging of Brain White Matter in Relapsing Remitting Multiple Sclerosis
Background: Quantitative Magnetization Transfer Imaging (QMTI) is often used to quantify the myelin content in multiple sclerosis (MS) lesions and normal appearing brain tissues. Also, automated classifiers such as artificial neural networks (ANNs) can significantly improve the identification and classification processes of MS clinical datasets.Objective: We classified patients with relapsing-r...
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Introduction: Multiple sclerosis (MS) is characterized by lesions in the white matter (WM) of the central nervous system. Magnetic resonance imaging is the most specific and sensitive method for diagnosis of multiple sclerosis. However, the ability of conventional MRI to show histopathologic heterogeneity of MS lesions is insufficient. Quantitative magnetization transfer imaging (qMTI) is a rel...
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Introduction Balanced steady state free precession (bSSFP) has been proposed recently for quantitative magnetization transfer (qMT) imaging [1]. Basically, bSSFP allows the determination of fundamental parameters of the two pool model [2], provided that T1 and B1 data are available. A critical point is the estimation of G0, which is the on-resonant singularity of the superlorentzian absorption ...
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Quantitative analysis of magnetization transfer images has the potential to allow a more thorough characterization of the protons, both bound and free, in a tissue by extracting a number of parameters relating to the NMR properties of the protons and their local environment. This work develops previously presented techniques to produce estimates of parameters such as the bound proton fraction, ...
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The magnetization transfer ratio reflects the integrity of tissue structure, including myelination and axonal density. Mean magnetization transfer ratio fell in 18 untreated patients with multiple sclerosis both in normal appearing grey (-0.25 pu/year, p < 0.001) and white matter (-0.12 pu/year, p = 0.004). Conversely, mean magnetization transfer ratio was stable in 20 alemtuzumab-treated patie...
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ژورنال
عنوان ژورنال: Journal of Magnetic Resonance Imaging
سال: 2007
ISSN: 1053-1807,1522-2586
DOI: 10.1002/jmri.20984